In my Arrow, the normal cabin air flow is in through the vents, out
through an exhaust duct mounted on the bottom of the cabin. However,
when I had a bad door seal, the suction around the door from the low
pressure above the wing reversed the flow when I had vents closed and
heater on low: in through the exhaust duct, out through the door.

Not sure whether this could happen with a Cessna, but I suspect it
could.