Guys who are used to computers seem to pick it up pretty fast.

I'm a computer guy but I got lost on the Garmin 430 a couple times when
I first flew behind one (at the time it was just a stupid box to me, I
really didn't need to turn it on). When in map mode if you turn the
little knob and the big knob a couple times you can quickly get lost.
The GX GPS has a "map" button to get you back to the map when you get
lost, the 430 could really use a "main menu" type button to get you
unstuck. I've power cycled them before.

-Robert