Here's a problem which seems to have a non-trivial solution.
At least, I've not been able to find a definitive answer to it, but
what do I know??

Suppose one wishes to land at an airport with a runway
that slopes at X degrees. The wind -- assumed to be directly
aligned with the runway -- is Y knots from the "high" end of
the runway.

Clearly, if Y is positive, one should try to land in the
"up-slope" direction to minimize one's ground roll. One
will be landing "up" and into a headwind. But what if
Y is negative? Clearly, if Y is just a few knots neg, one would
still land "up-slope", because the braking effect of rolling
out up-hill more than compensates for the higher landing
speed due to the tail wind.

If Y is negative and more substantial, which way should
one land? At some point, it makes sense to switch to the
other end of the runway -- landing downhill -- to take advantage
of the (now) headwind. But how does one establish which way
to land, assuming no clues from other traffic in the pattern? The
aim is to select a direction, given X and Y, which would result
in the smaller ground roll.

Rule of thumb responses are interesting, but better would be
a full mathematical treatment. Presumably, a proper treatment
would need to include touch-down speed too, and perhaps
gross weight as well.

Its more than an academic question for me. My home airport
has a 3 degree runway, and some local airports are even
steeper.