James Robinson writes:

The two approaches to defending against the charge in court are typically
self-defense, or what is called supervening cause. That would be something
like the person wouldn't have died if the ambulance personnel hadn't made a
mistake.

Nobody would have died if the pilot had not screwed up.

Other than that, if you commit a crime, and somebody dies for any cause
that can be remotely connected to the crime, you are in trouble.

The notion of pilot as sole in command would also be eroded by this.