Peter Dohm writes:

You forgot about the all-important "pause button" to facilitate potty-stops,
and visits to the fridge, without the dsiruption and delay associated with a
real stop enroute...

No need to pause the sim. You can visit the toilet or the galley in real life
while the flight continues, so you can do it in the sim as well.

An advantage to the sim, though, is that even the smallest aircraft have
toilets and galleys. Nevertheless, I try to keep my flights on toilet-free
aircraft limited to potty range.