VOR-DME writes:

O.P. did not state whether VFR or IFR, did not indicate a preference to fly
airways or whether he wished to avoid special use airspace. He could file
direct (or just fly) after checking airspace status.

Direct might be a challenge, since KPHX-KMYF direct would take him through
half a dozen restricted areas, some of which are continuously active and
extend to 80,000 feet MSL (missile firing ranges). V66 is a corridor that
passes between the restricted areas (in fact, it looks like the restricted
areas and airway were deliberately designed that way), and it's only 10 nm
longer than a direct route (a 4% increase).

The Great American West is filled with wide open spaces, but unfortunately the
U.S. military has confiscated many of them, especially in the desert
southwest.