I have heard evidence that physical conditioning has a very low correlation with the tolerance of lower oxygen levels at altitude. This came from someone who regularly teaches classes in altitude oxygen deprivation and hypoxic conditions. He has done hundreds of demonstrations with class volunteers and says that other than regular smokers, asthma etc, everyone is different, no matter if you run 6 miles a day or sit in a chair playing video games eating Cheetos, makes no difference in predicting the altitude you will start going hypoxic.
As a result, I set the EDS at 5,000 feet.